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1st Winter On-line School on “Brain Clearance Meets Complex Systems”
14-15 December 2021
Venue: Saratov State University, Saratov, Russia

Anatoly Karavaev

Anatoly Karavaev

Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia Saratov Branch of the Institute of RadioEngineering and Electronics of Russian Academy of Sciences, Zelyonaya, 38, Saratov 410019, Russia

“Revealing signs of opening the blood-brain barrier using spectral analysis and calculation of nonlinear characteristics of intracranial electroencephalograms”

We analyzed the two-channel signals of the local fields potentials of rats from invasive EEG electrodes. We used linear methods of spectral analysis and calculation of the coherence function. In addition, using nonlinear methods of analysis of directional connections using the simulation of instantaneous phases of oscillations EEG and cross recurrence analysis, the relationships between EEG derivations were analyzed. Signal analysis was carried out in the low-frequency range, including slow wave activity (0.1-0.05 Hz), d-range (1-4 Hz) and q-range (4-7 Hz).

It has been shown that the spectral power density increases, and the coherence function between leads decreases during the transition from the waking state to the sleep state and further increases after sound exposure and in the state of anesthesia. The quantitative index maximal diagonal line significantly increases with the opening of the BBB, and the directional coupling coefficient significantly decreases in the q-range.

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