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1st Winter On-line School on “Brain Clearance Meets Complex Systems”
14-15 December 2021
Venue: Saratov State University, Saratov, Russia

Alexey Semyanov,

Alexey Semyanov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. Faculty of Biology, Moscow State University, Moscow, Russia. Sechenov First Moscow State Medical University, Moscow, Russia.

“The brain active milieu”

We propose the morphofunctional concept of the ‘active milieu’ of the brain, which is based on the dynamic interposition and interaction among compartments of neurons, astrocytes, oligodendrocytes, microglia, blood vessels, extracellular space, and extracellular matrix. The active milieu integrates previous concepts of synaptic and extrasynaptic signaling, multipartite synapse, neurovascular unit, and volume transmission.

Certificate