Sang-Suk Lee
College of Health and Medical Sciences, Sangji University, Wonju 26339, Republic of Korea
Immunotherapeutic effect of anti-CD3 monoclonal antibody on Primo Vessels inside Lymph Vessels
Foralumab, used as an immunotherapeutic for COVID-19, works by binding to CD3 in the T-cell complex, which inhibits a cytokine storm through three major processes: antigenic modulation, anergy, and apoptosis. Our study showed that injecting the Foralumab into the lymph node of rabbits inflamed with LPS resulted in a thicker and an apparent floating primo vessel, indicating that Foralumab induced changes in the lymphatic immune system. Our findings suggested a possible functional role of the PVS in pathophysiological conditions.
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